HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Aminomorpholine → 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-morpholin-4-yl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Aminomorpholine | HCID 20315 | — |
| Reactant | 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-nicotinic acid | HCID 67497992 | — |
| Product | 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-morpholin-4-yl-nicotinamide | HCID 57334346 | 76% |
Reaction Steps
As described for example 10b, 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-nicotinic acid (68 mg, 0.21 mmol) was converted, using N-aminomorpholine instead of 4-aminotetrahydropyran, to the title compound (65 mg, 76%) which was obtained as a white solid. MS: m/e=413.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742097B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-dc6400c2fa964826864048d7aa839d3f |
| Source note | uspto-grants-2014_06 |