HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(2-hydroxy-ethyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-nicotinic acid | HCID 67497992 | — |
| Product | 6-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-N-(2-hydroxy-ethyl)-nicotinamide | HCID 57334348 | 72% |
Reaction Steps
As described for example 10b, 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-nicotinic acid (68 mg, 0.21 mmol) was converted, using ethanolamine instead of 4-aminotetrahydropyran, to the title compound (55 mg, 72%) which was obtained as an off white solid. MS: m/e=372.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742097B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-bb70facadfab4f88ad2e1db235a98dd4 |
| Source note | uspto-grants-2014_06 |