HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → N-Isopropyl-6-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 6-(3-Methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinic acid | HCID 67498281 | — |
| Product | N-Isopropyl-6-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide | HCID 57334648 | 71% |
Reaction Steps
As described for example 26b, 6-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinic acid (76 mg, 0.24 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (61 mg, 71%) which was obtained as a white solid. MS: m/e=353.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742097B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-a38a8d063dc049f78a265510df61b1a2 |
| Source note | uspto-grants-2014_06 |