Ethanol → HCID 57334945, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine (558 mg, 1.75 mmol) in ethanol (8 mL) was added sodium carbonate (185 mg, 1.745 mmol) followed by 1,1′-bis(diphenylphosphino) ferrocene (97 mg, 0.18 mmol) and palladium(II) acetate (40 mg, 0.18 mmol). The reaction flask was filled with Ar three times after a short evacuation. The fourth time the flask was flushed with CO-gas (balloon). The mixture was stirred under CO atmosphere at 50° C. over night, then cooled to room temperature and filtered over dicalite and washed well with DCM. The filtrate was then evaporated. Purification by chromatography (silica, 0 to 50% ethyl acetate in heptane) afforded the title compound (500 mg, 80%) as an off white solid. MS: m/e=358.2 [M+H]+.

Provenance & Evidence