N-Aminomorpholine → HCID 57335096, compound

HRID 402402Notes

Reaction equation

HRID 402402 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[N:11][N:10]([CH3:13])[C:9]=2[CH2:14][O:15][C:16]2[N:21]=[N:20][C:19]([C:22]([OH:24])=O)=[CH:18][CH:17]=2)=[CH:4][CH:3]=1.[NH2:25][N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[N:26]1([NH:25][C:22]([C:19]2[N:20]=[N:21][C:16]([O:15][CH2:14][C:9]3[N:10]([CH3:13])[N:11]=[N:12][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:17][CH:18]=2)=[O:24])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 67498530HCID 67498530, compound

Product 1

HCID 57335096HCID 57335096, compoundYield 29%

Procedure

As described for example 42b, 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid (67 mg, 0.20 mmol) was converted, using 4-aminomorpholine instead of 4-aminotetrahydropyran, to the title compound (25 mg, 29%) which was obtained as a white solid. MS: m/e=414.3 [M+H]+.

Sources & evidence

ORD record
ord-c9ea02181aeb440c9647145347378431
Source dataset
uspto-grants-2014_06
Patent number
US08742097B2

Reaction notes

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