Isopropylamine → 6-(3-Methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-ylmethoxy)-pyridazine-3-carboxylic acid isopropylamide
Reaction equation
[CH3:1][N:2]1[C:6]([CH2:7][O:8][C:9]2[N:14]=[N:13][C:12]([C:15]([OH:17])=O)=[CH:11][CH:10]=2)=[C:5]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)[N:4]=[N:3]1.[CH:24]([NH2:27])([CH3:26])[CH3:25]>>[CH:24]([NH:27][C:15]([C:12]1[N:13]=[N:14][C:9]([O:8][CH2:7][C:6]2[N:2]([CH3:1])[N:3]=[N:4][C:5]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:10][CH:11]=1)=[O:17])([CH3:26])[CH3:25]Participants
3
Procedure
As described for example 48b, 6-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (98 mg, 0.31 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (101 mg, 91%) which was obtained as an off white solid. MS: m/e=354.2 [M+H]+.
Sources & evidence
- ORD record
- ord-cb6dcbe2019a475d992da971459f6059
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08742097B2
Reaction notes
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