N-Aminomorpholine → 6-[5-(5-Fluoro-pyridin-2-yl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid morpholin-4-ylamide

Participants

Reaction Steps

As described for example 51c, 6-[5-(5-fluoro-pyridin-2-yl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid (50 mg, 0.15 mmol) was converted, using N-aminomorpholine instead of 2-amino-2-methyl-1-propanol, to the title compound (35 mg, 56%) which was obtained as a light yellow solid. MS: m/e=415.3 [M+H]+.

Provenance & Evidence