4-Aminotetrahydropyran → 6-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-N-(tetrahydro-pyran-4-yl)-nicotinamide

Participants

Reaction Steps

As described for example 56b, 6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid (49 mg, 0.15 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (45 mg, 82%) which was obtained as a light yellow solid. MS: m/e=366.1 [M+H]+.

Provenance & Evidence