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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 402441Generated: October 30, 2026

6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid → 6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)-N-isopropylnicotinamide

https://huagongshe.com/reaction/402441

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acidHCID 67498466—
Reactant6-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-nicotinic acidHCID 67498745—
Product6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)-N-isopropylnicotinamideHCID 5733555778%

Reaction Steps

As described for example 62, 6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid (55 mg, 0.17 mmol), instead of 6-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-nicotinic acid, was converted to the title compound (48 mg, 78%) which was obtained as a white foam. MS: m/e=370.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08742097B2
Source datasetuspto-grants-2014_06
ORD IDord-5c0e407227db4e4ca07507aea7c581fd
Source noteuspto-grants-2014_06