4-Aminotetrahydropyran → 6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)-N-(tetrahydro-2H-pyran-4-yl)nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	4-Aminotetrahydropyran	HCID 419223	—
Reactant	6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid	HCID 67498466	—
Product	6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)-N-(tetrahydro-2H-pyran-4-yl)nicotinamide	HCID 57335558	61%

Reaction Steps

As described for example 67, 6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid (55 mg, 0.17 mmol), was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (42 mg, 61%) which was obtained as a white foam. MS: m/e=412.2 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08742097B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-feb92e48a80d4f9e92a7cb39df7e1a56
Source note	uspto-grants-2014_06