HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Aminomorpholine → 6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)-N-morpholinonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Aminomorpholine | HCID 20315 | — |
| Reactant | 6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid | HCID 67498466 | — |
| Product | 6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)-N-morpholinonicotinamide | HCID 57335695 | 66% |
Reaction Steps
As described for example 67, 6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid (78 mg, 0.24 mmol), was converted, using 4-aminomorpholine instead of isopropylamine, to the title compound (65 mg, 66%) which was obtained as an off white foam. MS: m/e=413.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742097B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-eb6d201d5146468883287fc99539194f |
| Source note | uspto-grants-2014_06 |