Cyclopropylamine → N-Cyclopropyl-6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	Cyclopropylamine	HCID 69828	—
Reactant	6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid	HCID 67498466	—
Product	N-Cyclopropyl-6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinamide	HCID 57335696	83%

Reaction Steps

As described for example 67, 6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid (78 mg, 0.24 mmol), was converted, using cyclopropylamine instead of isopropylamine, to the title compound (72 mg, 83%) which was obtained as a white foam. MS: m/e=368.2 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08742097B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-817e4c389c9a420e8e6b48acbbe7ff42
Source note	uspto-grants-2014_06