3-Amino-3-methyloxetane → 5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (3-methyl-oxetan-3-yl)-amide

Participants

Reaction Steps

As described for example 80c, 5-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (83 mg, 0.25 mmol), was converted, using 3-methyl-3-oxetanamine instead of 4-aminotetrahydropyran, to the title compound (63 mg, 63%) which was obtained as an off white solid. MS: m/e=399.2 [M+H]+.

Provenance & Evidence