Ethyl 4,4,4-trifluoroacetoacetate → HCID 136376523, compound

Participants

Reaction Steps

A solution of 3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-amine (830 mg, 4.34 mmol) and 4,4,4-Trifluoro-3-oxo-butyric acid ethyl ester (960 mg, 5.21 mmol) in acetic acid (5 ml) was irradiated using a microwave at 150° C. for 1.5 h. After completion of the reaction, ice-cold water was added and the reaction mixture was stirred for 10 min. The precipitate was filtered, washed twice with pentane and dried under vacuum to yield 900 mg (67%) of the title compound. [1H-NMR (CDCl3, 300 MHz): δ 13.6 (s, 1H), 7.51-7.05 (m, 4H), 6.75 (s, 1H), 4.21 (s, 3H); LCMS RtA=1.459 min; [M+H]+=312.1]

Provenance & Evidence