Hydrochloric Acid → HCID 67209398, compound

Participants

Reaction Steps

To a solution of ethyl 2-(3-(2-fluorophenyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yloxy)acetate (180 mg, 0.45 mmol) in a mixture of EtOH, THF and water (2 ml/1 ml/0.5 ml) was added LiOH.H2O (76.1 mg, 1.81 mmol). The reaction mixture was stirred for 1 h at rt. Aqueous HCl was then added to adjust the reaction mixture to pH ˜2. The resulting precipitate was filtered off and washed twice with pentane (2×10 mL). The obtained solid was dried under vacuum to furnish 130 mg (78%) of the title compound. [1H-NMR (CDCl3, 300 MHz) δ 7.58-6.95 (m, 5H), 5.25 (s, 2H), 4.15 (s, 3H); LCMS RtA=1.681 min; [M+H]+=370.1]

Provenance & Evidence