反应详情

Methyl hydrazine (12 ml, 228 mmol) was added dropwise to dimethyl fumarate (32.8 g, 228 mmol) at −5° C. The mixture was stirred under warming to rt for 16 h and then heated to 100° C. for 3 h. The crude reaction product (36 g, quantitative) was used for the next step without purification. [[M+H]+=159.1]

1. temperatureheated to 100° C. for 3 h
2. customThe crude reaction product (36 g, quantitative)
3. customwas used for the next step without purification