Cesium carbonate → 6-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one

Participants

Reaction Steps

169 μL (1.24 mmol, 1.1 eq) of p-methoxybenzylchloride were added to a suspension of 200 mg (1.13 mmol) of 6-fluoro-isoquinolinone (8) and 368 mg (1.36 mmol, 1.2 eq) of Cs2CO3 in 3 mL of DMF. The mixture was stirred for 2 h and then poured on ice. The precipitate was filtered, washed with water and dried to yield 300 mg of the title compound. Rt=1.76 min (Method B). Detected mass: 284.14 (M+H+).

Provenance & Evidence