Sodium Iodide → HCID 68553449, compound

Participants

Reaction Steps

To a solution of 0.4 g (1 mmol) of 6-(cis-4-amino-cyclohexyloxy)-2-(4-methoxy-benzyl)-7-methyl-2H-isoquinolin-1-one (26, step b), 0.31 g (2 mmol) sodium iodide and 0.35 g (2.5 mmol) potassium carbonate in 40 ml DMF were added dropwise 0.24 g (1.1 mmol) 1,4-dibromobutane. After stirring at room temperature for 2 days the mixture was diluted with water and extracted with ethyl acetate. After drying and evaporation the residue was purified by chromatography to yield 182 mg of 2-(4-methoxy-benzyl)-7-methyl-6-(4-pyrrolidin-1-yl-cyclohexyloxy)-2H-isoquinolin-1-one.

Provenance & Evidence