Trifluoroacetic acid → HCID 68549477, compound

Participants

Reaction Conditions

Reaction Steps

130 mg (0.32 mmol) 6-(cis-4-amino-cycloheptyloxy)-2-(4-methoxy-benzyl)-7-methyl-2H-isoquinolin-1-one were dissolved in 730 mg (6.4 mmol) trifluoroacetic acid and the mixture was heated for 2 h in a microwave oven at 150° C. Then the excess trifluoroacetic acid was distilled off in vacuo and the residue was diluted with water and the solution was made alkaline. After extraction with dichloromethane, drying over magnesium sulfate and evaporation 24 mg of 6-(cis-4-amino-cycloheptyloxy)-7-methyl-2H-isoquinolin-1-one (47) were obtained. Rt=0.96 min (Method B). Detected mass: 287.3 (M+H+).

Provenance & Evidence