反应详情

A solution of 895 mg (4.88 mmol) of 1-allyl-5-(tert-butyl-dimethyl-silanyloxy)-cyclooctylamine (63) in 15 mL of methanol was treated with 52 mg of 10% palladium on activated carbon and the mixture was stirred overnight under a hydrogen atmosphere (1 atm) at room temperature. The catalyst was removed by filtration, and the filtrate was evaporated in vacuo to give 0.794 g of the title compound (64). Rt=0.56 min, 0.62 min min (Method C). Detected mass: 186.3 (M+H+).

1. customThe catalyst was removed by filtration
2. customthe filtrate was evaporated in vacuo