3,5-Difluorobenzylamine → N2,3-bis(benzyloxy)-N5-(3,5-difluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Participants

Reaction Steps

3,5-difluorobenzylamine (0.02 g, 0.154 mmol, 2.5 eq) and N,7-bis(benzyloxy)-3-oxo-1,3-dihydrofuro[3,4-c]pyridine-6-carboxamide (0.030 g, 0.077 mmol, 1 eq) were heated neat at 70° C. for 30 min. The crude product was purified by silica gel (100% ethyl acetate) yielding 0.011 g of N2,3-bis(benzyloxy)-N5-(3,5-difluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide (15% yield) as a white solid; MS-ESI m/z 534 [MH]+.

Provenance & Evidence