HCID 44540570, compound → HCID 67056187, compound

HRID 402574Notes

Reaction equation

HRID 402574 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([NH:8][C:9]2[CH:14]=[N:13][C:12]([C:15]([O:17][CH3:18])=[O:16])=[C:11]3[O:19]C(C)(C)[O:21][CH2:22][C:10]=23)=[O:7])=[CH:4][CH:3]=1>C(O)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[C:10]([CH2:22][OH:21])=[C:11]([OH:19])[C:12]([C:15]([O:17][CH3:18])=[O:16])=[N:13][CH:14]=2)=[O:7])=[CH:25][CH:26]=1

Participants

3

Reactant 1

HCID 44540570HCID 44540570, compound2×

Product 1

HCID 67056187HCID 67056187, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Methyl 5-(4-fluorobenzamido)-3-hydroxy-4-(hydroxymethyl)picolinate (23e) was synthesized from methyl 5-(4-fluorobenzamido)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate (Compound 23d) and formic acid as described above. MS-ESI m/z 361 [MH]+.

Sources & evidence

ORD record
ord-e87428016ca440f0a54fdcfcbbfc45c0
Source dataset
uspto-grants-2014_06
Patent number
US08742123B2

Reaction notes

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