HCID 58360247, compound → HCID 44540665, compound

Participants

Reaction Steps

A solution of methyl 5-((4-fluorophenoxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate 28a (0.129 g, 0.37 mmol) in 3 mL of formic acid was stirred at 23° C. for 2 h and then it was concentrated. The crude residue was purified by chromatography (SiO2) with hexanes:ethyl acetate (3:7) as eluent to afford the title compound as a white solid: LC-MS (M+H)+ m/z 308; 1H NMR (DMSO-d6): 1.39 (s, 6H), 4.80 (s, 2H), 4.89 (s, 2H), 5.01 (s, 2H), 7.39-7.46 (m, 5H), 8.38 (s, 1H), 10.04 (s, 1H).

Provenance & Evidence