N,N-diethylpiperidin-4-amine dihydrochloride → N,N-diethylpiperidin-4-amine

HRID 402709Notes

Reaction equation

HRID 402709 reaction equation
Cl.Cl.[CH2:3]([N:5]([CH2:12][CH3:13])[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:4]>O.[OH-].[Na+]>[CH2:12]([N:5]([CH2:3][CH3:4])[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)[CH3:13]

Participants

4

Reactant 1

HCID 53410672N,N-diethylpiperidin-4-amine dihydrochloride

Product 1

HCID 2758239N,N-diethylpiperidin-4-amineYield 57,256.398%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

To a solution of 4-(diethylamino)piperidine dihydrochloride (3.0 g, 0.019 mmol) in water (20 mL), 2M sodium hydroxide solution (5.0 mL) was added at ambient temperature. The mixture was stirred for 30 min. The solvent was removed under reduced pressure, and methanol (10 mL) was added to the crude material, then the residue was removed by filtration. The filtrate was concentrated and dried to afford 4-(diethylamino)piperidine (1.7 g, y. 77%) as solid.

Workup

  1. customThe solvent was removed under reduced pressure, and methanol (10 mL)
  2. additionwas added to the crude material
  3. customthe residue was removed by filtration
  4. concentrationThe filtrate was concentrated
  5. customdried

Sources & evidence

ORD record
ord-e3c7ab6f7b484b4da9c0182a6621a93e
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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