Benzyl Chloride → Methyl 2,3-bis(benzyloxy)benzoate

HRID 402742Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 402742
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[OH:11].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]=1[O:11][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

3

Edukt 2

HCID 7503Benzyl ChlorideHCID 75484Methyl 2,3-Dihydroxybenzoate

Produkt 1

HCID 10665397Methyl 2,3-bis(benzyloxy)benzoate

Versuchsvorschrift

In one embodiment, the compounds can be prepared as shown in Scheme II. A dihydroxy benzoic acid methyl ester is reacted with benzyl chloride, to produce a Bis-benzyloxy benzoic acid methyl ester (1). The Bis-benzyloxy benzoic acid methyl ester can then be heated with LiOH to give a Bis-benzyloxy benzoic acid (2). The Bis-benzyloxy benzoic acid (2) is then reacted with an aminophenyl to produce a phenyl-benzamide (3). The phenyl-benzamide (3) is then reacted with hydrazine to give a triazol (4). The hydroxy groups can then be unprotected in the presence of palladium on charcoal to give the final product.

Aufarbeitung

  1. customIn one embodiment, the compounds can be prepared

Quellen und Nachweise

ORD-Eintrag
ord-db7e5c64885149b6b3e793f919bfc830
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08742133B2

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