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Potassium Carbonate → 1118915-78-8
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (Chloro(phenylmethoxy)phosphoryl)oxymethylbenzene | HCID 4641201 | — |
| 反応物 | benzyl 3-(2-(benzyloxy)-4-(ethoxymethoxy)-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate | HCID 67339760 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 1118915-78-8 | HCID 135565962 | — |
反応手順
Dibenzyl phosphorochloridate was added to the solution of benzyl 3-(2-(benzyloxy)-4-(ethoxymethoxy)-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate and potassium carbonate in acetone. The reaction mixture was stirred at room temperature overnight. After removal of solvent, the reaction mixture was purified by column chromatography to produce pale yellow oil, which was hydrogenated to give the desired.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08742133B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-ba3528f8eb2a40c6995f3c6584758949 |
| 出典メモ | uspto-grants-2014_06 |