HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 8-cyclopropyl-4,4-dimethyl-3,4-dihydro-2H-thiochromene-6-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | Potassium cyclopropyltrifluoroborate | HCID 23697338 | — |
| Reactant | 8-Chloro-4,4-dimethylthiochroman-6-carbaldehyde | HCID 86676817 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | 8-cyclopropyl-4,4-dimethyl-3,4-dihydro-2H-thiochromene-6-carbaldehyde | HCID 86685268 | — |
Reaction Steps
Using essentially the same procedure as Example 5-22, Step 4, Pd(OAc)2 (5.18 mg, 0.02 mmol), X-Phos (22.0 mg, 0.05 mmol), potassium carbonate (319 mg, 2.30 mmol), potassium cyclopropyltrifluoroborate (125 mg, 0.84 mmol), and 8-chloro-4,4-dimethyl-3,4-dihydro-2H-thiochromene-6-carbaldehyde (185 mg, 0.77 mmol, Example 5-29, Step 3) afforded the desired product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742110B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-02a5a7ac6ff043f9ac7a5a2a786cf475 |
| Source note | uspto-grants-2014_06 |