Acetic Acid → HCID 89583168, compound

Participants

Reaction Steps

To a mixture of half of the crude methyl 4-{8-[(4′-fluoro-2,6-dimethylbiphen-4-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate from Step 3 (˜0.065 mmol) in ethanol (1 mL) was added excess aqueous potassium hydroxide and the reaction was stirred at room temperature for 24 hours. The mixture was then acidified with acetic acid and the title product (5.4 mg) was isolated by mass directed reverse phase (C18) chromatography (0.1% ammonium hydroxide) and evaporation of the product fractions.

Provenance & Evidence