反应详情

Iodine (7.4 mmol) and bis(trifluoroacetoxy)iodobenzene (8.16 mmol) were added to a solution of the tri-boc protected dopa ester analog 16 (5.7 mmol) in anhydrous dichloromethane (60 mL) under argon. The reaction mixture was stirred at room temperature for 40 min and then quenched with a saturated solution of sodium thiosulfate. The organic layer was washed with water (3×10 mL), dried with anhydrous sodium sulfate, filtered and evaporated in a rotary evaporator. The product was purified by silica gel column chromatography using 15-20% ethyl acetate in hexane as the mobile phase to give the iodo analog 17 as white foam in 77% yield.

1. customquenched with a saturated solution of sodium thiosulfate
2. washThe organic layer was washed with water (3×10 mL)
3. dry with materialdried with anhydrous sodium sulfate
4. filtrationfiltered
5. customevaporated in a rotary evaporator
6. customThe product was purified by silica gel column chromatography