Trifluoroacetic acid → HCID 86659573, compound

Participants

Reaction Steps

An amount of 410 mg (0.336 mmol) of the compound from example 24A was introduced in 2 ml of dichloromethane, admixed with 0.259 ml (3.364 mmol) of trifluoroacetic acid and stirred at RT overnight. The reaction mixture was then concentrated and the residue was purified by means of preparative HPLC (eluent gradient: acetonitrile/water 10:90→95:5 with addition of 0.1% TFA). This gave 191 mg (50% of theory) of the target compound.

Provenance & Evidence