Trifluoroacetic acid → HCID 86659576, compound

Participants

Reaction Steps

An amount of 190 mg (0.156 mmol) of the compound from example 22A was introduced in 1 ml of dichloromethane, admixed with 0.120 ml (1.559 mmol) of trifluoroacetic acid and stirred at RT overnight. The reaction mixture was then concentrated and the residue was purified by means of preparative HPLC (eluent gradient: acetonitrile/water 10:90→95:5 with addition of 0.1% TFA). This gave 76 mg (43% of theory) of the target compound.

Provenance & Evidence