Trifluoroacetic acid → HCID 131731435, compound

Participants

Reaction Steps

An amount of 70 mg (0.058 mmol) of the compound from example 31A was introduced in 0.5 ml of dichloromethane, admixed with 0.045 ml (0.578 mmol) of trifluoroacetic acid and stirred at RT. After 3 hours, again, the same amount of trifluoroacetic acid was added and the mixture was stirred at RT overnight. The reaction mixture was then concentrated and the residue was purified by means of preparative HPLC (eluent gradient: acetonitrile/water 10:90→95:5 with addition of 0.1% TFA). This gave 45 mg (55% of theory) of the target compound.

Provenance & Evidence