Trifluoroacetic acid → HCID 88545532, compound

Participants

Reaction Steps

An amount of 79 mg (0.080 mmol) of the compound from example 32A was introduced in 0.5 ml of dichloromethane, admixed with 0.061 ml (0.798 mmol) of trifluoroacetic acid and stirred at RT. After 3 hours, again, the same amount of trifluoroacetic acid was added and the mixture was stirred at RT overnight. The reaction mixture was then concentrated and the residue was purified by means of preparative HPLC (eluent gradient: acetonitrile/water 10:90→95:5 with addition of 0.1% TFA). This gave 54 mg (65% of theory) of the target compound.

Provenance & Evidence