Hydrochloric Acid → HCID 46840906, compound

Participants

Reaction Steps

An amount of 200 mg (0.196 mmol) of the compound from example 46A was introduced in 60 ml of dichloromethane, and hydrogen chloride gas was passed into this solution. After one hour of stirring at RT, the solution was concentrated under reduced pressure to a volume of approximately 30 ml and was admixed with 50 ml of ethyl acetate. The precipitated solid was isolated by suction filtration, washed with ethyl acetate and dried under a high vacuum at 100° C. for 5 hours. This gave 151 mg (86% of theory) of the target compound.

Provenance & Evidence