5-Fluoro-2-nitrophenol → 2-Amino-5-fluorophenol

Participants

Reaction Steps

To 5-fluoro-2-nitrophenol (26.63 g, 170 mmol) in ethanol under N2 atmosphere was added palladium on carbon (10 wt %, 250 mg, 0.235 mmol). The mixture was flushed with H2 and stirred at RT under H2 (balloon) until complete conversion according to thin layer chromatography (TLC) analysis. Pd/C was removed by filtration and the filtrate was concentrated to yield 21.6 g of the title compound.

Provenance & Evidence