Dichloromethane → HCID 10411615, compound

Participants

Reaction Steps

In a 25 mL vial, 123.1 mg (0.388 mmol) of 4-ethyl-benzoic acid N′-(1-tert-butyl-heptyl)-hydrazide were dissolved in 5 mL CH2Cl2. 3 equivalents of PS-NMM (polystyrene-SO2NH(CH2)3-morpholine, Argonaut Tech.) were added, followed by 3 mL CH2Cl2 to create a stirable suspension. One equivalent of acid chloride was added, and the reaction mixture was stirred overnight. The next day, 2 equivalents of AP-NCO resin (isocyante scavenger, ArgonautTech.) and 2 equivalents of AP-trisamine (polystyrene-CH2NHCH2CH2NH(CH2CH2NH2)2, Argonaut Tech.) were added with 3 mL CH2Cl2. The mixture was stirred for four hours and the resins were filtered. The reaction was analyzed by TLC, the solvent was removed, and the residue was dried under vacuum. After silica gel column chromatography using a 0-100% ether in hexane gradient, 107.5 mg of 2-methoxy-nicotinic acid N-(1-tert-butyl-heptyl)-N′-(4-ethyl-benzoyl)-hydrazide were isolated.

Provenance & Evidence