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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 403215Generated: October 30, 2026

3-(2-Ethylpiperidin-1-yl)propan-1-amine → 3-(4-chlorobenzyl)-N-(3-(2-ethylpiperidin-1-yl)propyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide

https://huagongshe.com/reaction/403215

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2-Ethylpiperidin-1-yl)propan-1-amineHCID 4117479—
Reactant3-(4-Chlorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylic acidHCID 45031015—
Product3-(4-chlorobenzyl)-N-(3-(2-ethylpiperidin-1-yl)propyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamideHCID 16066792—

Reaction Steps

55 mg (42%) of the target compound was obtained in the same manner of Example 1, using 3-(4-chloro-benzyl)-2,4-dioxoquinazoline-7-carboxylic acid (90 mg, 0.272 mmol) obtained in Example 1 and 3-(2-ethyl-piperidine-1-yl)-propylamine (101 mL, 0.598 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748422B2
Source datasetuspto-grants-2014_06
ORD IDord-c408deb9867d46a59cde7c3d985b9522
Source noteuspto-grants-2014_06