HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Tirbanibulin | HCID 23635314 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | N-Benzyl-2-(5-{4-[2-(morpholin-4-yl)ethoxy]phenyl}pyridin-2-yl)acetamide--hydrogen chloride (1/2) | HCID 24989633 | — |
Reaction Steps
The resulting methyl 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetate (7) and benzyl amine were coupled in anisole at high temperature to afford 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Compound 134). An HCl solution formed by adding acetyl chloride to absolute ethanol was added to Compound 134 to form the bis-HCl salt, 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide dihydrochloride, (KX2-di-HCl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748423B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-ab257d0b77fc441db0bbd9164082b43d |
| Source note | uspto-grants-2014_06 |