Dichloromethane → HCID 58563043, compound

Participants

Reaction Conditions

Reaction Steps

To a vigorously stirred mixture of (S)-4-amino-4-(5-bromo-2-fluoro-phenyl)-2-methyl-pentan-2-ol (intermediate A14A) (2.22 g; 7.7 mmol) in sat. aqueous NaHCO3-sol. (25 ml) and dichloromethane (DCM) (35 ml) at 0° C. was added chloroacetyl chloride (672 μl, 8.5 mmol) and the mixture was stirred at 0° C. for 30 min Diluted with water, brine and ethyl acetate (EtOAc), separated phases, dried organic layer over sodium sulphate. Removal of the solvent in vacuum left the crude product as a colourless oil (3.11 g, 111%), which was used in the next step without further purification. MS (ISP): m/z=366.0 [(M+H)+], 368.0 [(M+2+H)+] and 370.0 [(M+4+H)+].

Provenance & Evidence