Heptane → HCID 68227180, compound

Participants

Reaction Steps

Prepared in an analogous manner as described for intermediate A27A from 2-Bromo-N—[(R)-1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-3-hydroxy-1-methyl-propyl]-acetamide (intermediate A15B) (700 mg; 2.82 mmol). After silica gel column chromatography with heptane and ethyl acetate the (R)-5-(5-bromo-2-fluoro-phenyl)-6,6-difluoro-5-methyl-[1,4]oxazepan-3-one (366 mg, 1.83 mmol, 65% yield) was obtained as a white solid. MS (ISP): m/z=337.0 [(M+H)+] and 339.0 [(M+2+H)+].

Provenance & Evidence