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HRID403247

反应详情

EQUATION

反应方程式

HRID 403247 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OCC(=S)N[C@](C)(c2cc(N)ccc2F)C1(F)F
HCID58563112

未命名化合物

结构：N#Cc1cnc2c(c1)CCCC2=O
HCID68227243

5,6,7,8-Tetrahydro-8-oxo-3-quinolinecarbonitrile

C10H8N2O

PRODUCTS

生成物

1
结构：CC1(C)OCC(=S)N[C@](C)(c2cc(NC3CCCc4cc(C#N)cnc43)ccc2F)C1(F)F
HCID86670907

未命名化合物

收率 63.2%

PROCEDURE

实验过程

Prepared in an analogous manner as described for intermediate A22A from (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5,7,7-trimethyl-1,4-oxazepane-3-thione (intermediate A19B) (102 mg, 320 μmol) and 8-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile (66.2 mg, 384 μmol). The 8-(3-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-1,4-oxazepan-5-yl)-4-fluorophenylamino)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (96 mg, 63.1%) was obtained as a white foam. MS (ISN): m/z=473.1 [(M−H)−].

WORKUP

后处理

  1. customPrepared in an analogous manner