HRID403252

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13778133

6-Chloro-1-benzofuran-3(2H)-one

C8H5ClO2

结构：CC1(C)OCC(=S)N[C@](C)(c2cc(N)ccc2F)C1(F)F

HCID58563112

未命名化合物

PRODUCTS

生成物

结构：CC1(C)OCC(=S)N[C@](C)(c2cc(NC3COc4cc(Cl)ccc43)ccc2F)C1(F)F

HCID86670908

1,4-Oxazepine-3(2H)-thione, 5-[5-[(6-chloro-2,3-dihydro-3-benzofuranyl)amino]-2-fluorophenyl]-6,6-difluorotetrahydro-5,7,7-trimethyl-, (5R)-

C22H22ClF3N2O2S

收率 50.7%

PROCEDURE

实验过程

Prepared in an analogous manner as described for intermediate A22A from (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5,7,7-trimethyl-1,4-oxazepane-3-thione (intermediate A19B) (96 mg, 302 μmol) and commercially available 6-chlorobenzofuran-3(2H)-one [CAS no 3260-78-4] (61.0 mg, 362 μmol) The (5R)-5-(5-(6-chloro-2,3-dihydrobenzofuran-3-ylamino)-2-fluorophenyl)-6,6-difluoro-5,7,7-trimethyl-1,4-oxazepane-3-thione (72 mg, 153 μmol, 50.7% yield) was obtained as a light yellow foam. MS (ISN): m/z=469.1 [(M−H)−] and 471.2 [(M+2-H)−].

WORKUP

后处理

customPrepared in an analogous manner