4-Fluoroaniline → HCID 68227496, compound

Participants

Reaction Steps

Prepared in an analogous manner as described for intermediate A9A or A13A from (R)-545-bromo-2-fluorophenyl)-6,6-difluoro-5,7,7-trimethyl-1,4-oxazepan-3-one (intermediate A16B) (300 mg, 819 μmol) and commercially available 4-fluoroaniline [CAS no 371-40-4] 4-fluoroaniline (157 μL, 1.64 mmol). The (R)-6,6-difluoro-5-(2-fluoro-5-(4-fluorophenylamino)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one (181 mg, 55.7%) was obtained as a light yellow foam. MS (ISP): m/z=397.0 [(M+H)+].

Provenance & Evidence