HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57497168, compound → HCID 60194542, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57497168 | HCID 57497168 | — |
| Reactant | (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine | HCID 58562966 | — |
| Product | HCID 60194542 | HCID 60194542 | 11.4% |
Reaction Steps
In an analogous manner as described for example 2 the reductive amination of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) (27.3 mg, 100 μmol) and 4-chloro-1-difluoromethyl-1H-pyrazole-3-carbaldehyde (19.9 mg, 110 μmol) yielded the title compound (5 mg, 11.4%) as a colorless oil. MS (ISP): m/z=438.2 [M+H]+and 440.1 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748418B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-adce5f2254d347f98578bfe4741f5204 |
| Source note | uspto-grants-2014_06 |