HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59625756, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | 1-(5-Chloro-2-fluorophenyl)-2,2,2-trifluoroethanone | HCID 59164193 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59625756 | HCID 59625756 | — |
Reaction Steps
A solution of compound 11c (1.5 g, 6.62 mmol), methyl 2-mercaptoacetate 11d (0.6 mL, 6.62 mmol), and Et3N (1.2 mL, 8.6 mmol) in acetonitrile (12 mL) was heated at 75° C. for 4 h. The reaction was diluted with EtOAc and water. The organic layer was concentrated and purified by flash column chromatography (silica gel, 10% EtOAc/hexanes) to provide compound 11e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748417B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-3068f6c8bfaa49eaac477d7715739ab3 |
| Source note | uspto-grants-2014_06 |