HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (7-Fluoro-benzooxazol-2-yl)-(R)-1-pyrrolidin-3-ylmethyl-amine, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (3S)-3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1514454 | — |
| Reactant | 2-Chloro-7-fluoro-1,3-benzoxazole | HCID 15428739 | — |
| Reactant | (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-ylmethyl-amine | HCID 59178006 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (7-Fluoro-benzooxazol-2-yl)-(R)-1-pyrrolidin-3-ylmethyl-amine, hydrochloride | HCID 131728780 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-ylmethyl-amine; hydrochloride (example 1, step 2) the title compound was prepared from (S)-3-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester and 2-chloro-7-fluoro-benzooxazole (Bioorganic & Medicinal Chemistry Letters 2007, 17, 4689) and subsequent cleavage of the tert-butyloxy carbonyl-protecting group through treatment with HCl in dioxane. MS (m/e): 236.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748430B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b4190d2963264336bbf9cc9378b06f62 |
| Source note | uspto-grants-2014_06 |