(4-Fluoro-2-methoxyphenyl)boronic acid → 5-(4-Fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine

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Reaction Steps

The title compound was prepared in analogy to example 1, intermediate b, from 5-chloro-pyridazin-4-ylamine (CAS RN 53180-92-0) and 4-fluoro-2-methoxyphenylboronic acid (CAS RN 179899-07-1) and using a gradient of n-heptane:ethyl acetate:methanol (100:0:0 to 0:100:0 to 0:50:50) for the chromatographic purification. Light yellow solid (37%). MS (ESI+): m/z=220.089 ([M+H]+).

Provenance & Evidence