3-Chloro-5-methanesulfonylbenzoic acid → 3-Chloro-5-methanesulfonyl-N-methyl-N-(5-o-tolyl-pyridazin-4-yl)-benzamide

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Reaction Steps

The title compound was prepared in analogy to example 1, from methyl-(5-o-tolyl-pyridazin-4-yl)-amine and 3-chloro-5-methanesulfonyl-benzoic acid. A second purification step using preparative HPLC (Gemini NX column) with a gradient of acetonitrile:water with 0.05% formic acid (80:20 to 98:2) gave the desired compound as a colorless solid (44%). MS (ESI+): m/z=416.083 ([M+H]+).

Provenance & Evidence