Trifluoroacetic acid → HCID 71766518, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 10, from 4-{3-[methyl-(5-o-tolyl-pyridazin-4-yl)-carbamoyl]-5-trifluoromethyl-benzenesulfonyl}-butyric acid tert-butyl ester (example 16), adding another batch of trifluoroacetic acid after 3 hours (395 mg, 267 μL, 3.46 mmol) and stirring at room temperature for additional 64 hours. The product was further purified by a second chromatography using an MPLC (Flashmaster) system eluting with a gradient of CH2Cl2:methanol (100:0 to 90:10). Colorless oil (57%). MS (ESI+): m/z=522.13 ([M+H]+).

Provenance & Evidence