HCID 86677205, compound → HCID 86677204, compound

Participants

Reaction Steps

A solution of 0.020 g (0.030 mmol) of tert-butyl(2S,5R)-2-(3-amino-4-{[(2.5)-2-(2-oxopyrimidin-1(2H)-yl)propanoyl]amino}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine-1-carboxylate from Step A above in 1 mL of glacial acetic acid under an atmosphere of nitrogen was heated to 100° C. for 1 h. The resulting solution was allowed to cool to ambient temperature and then concentrated in vacuo to afford the title compound as a light brown gum that was used without further purification. LC/MS: m/z (ES) 644.5 (MH)+.

Provenance & Evidence